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What is the role of cholesterol in biological membranes?

Cholesterol plays a crucial role in maintaining the structure and function of biological membranes, especially in animal cells.

Here’s how it contributes:

  1. Maintains membrane fluidity:
    • Cholesterol helps keep the cell membrane fluid and flexible.
    • At high temperatures, it stabilizes the membrane by reducing excess movement of phospholipid molecules.
    • At low temperatures, it prevents the membrane from becoming too rigid by stopping phospholipids from packing too closely together.
  2. Provides membrane stability:
    • Cholesterol fits between phospholipids in the bilayer, giving the membrane mechanical strength and stability without making it too stiff.
  3. Reduces membrane permeability:
    • It makes the membrane less permeable to small water-soluble molecules and ions, helping the cell control what enters and leaves.
  4. Helps form lipid rafts:
    • Cholesterol gathers with certain lipids and proteins to form lipid rafts, which are important for cell signaling and transport of molecules across the membrane.
  5. Supports membrane protein function:
    • By maintaining proper membrane fluidity and structure, cholesterol helps membrane proteins (like receptors and enzymes) function properly.

In short:
Cholesterol helps regulate membrane fluidity, adds strength and stability, reduces permeability, and supports cell signaling—making it an essential component of animal cell membranes.

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